Wham
A suite of tools (wham and whamg) for sensitive and accurate structural variant detection and association testing from genomic sequencing data.
What is Wham?
wham is a bioinformatics software suite for detecting structural variants (SVs) like deletions, duplications, and inversions from whole-genome sequencing data. It solves the problem of accurately identifying large genomic rearrangements, which are challenging to detect with standard variant callers, and includes statistical tests to find SVs associated with diseases. The suite offers two tools: whamg for general SV discovery and wham for sensitive detection and association testing.
Bioinformaticians, computational biologists, and genomics researchers working with whole-genome sequencing data who need to identify structural variants for population studies, disease research, or clinical genomics.
Developers choose wham because it provides a dual-approach suite—combining the accuracy of whamg for discovery with the sensitivity and association testing capabilities of wham—all within a single, pipeline-friendly toolset that outputs standard VCF and integrates with platforms like gkno and bcbio-nextgen.
Overview
Structural variant detection and association testing
Use Cases
Best For
- Identifying structural variants in human whole-genome sequencing data
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