htslib
A C library for reading and writing high-throughput sequencing data formats like SAM, CRAM, and VCF.
What is htslib?
HTSlib is a C library that provides programmatic access to high-throughput sequencing data formats such as SAM, CRAM, and VCF. It solves the problem of fragmented tooling by offering a unified, efficient interface for reading and writing genomic data files, serving as the core engine for widely used bioinformatics applications.
Bioinformatics developers and researchers who need to process genomic sequencing data programmatically, particularly those building tools that work with SAM, CRAM, or VCF formats.
Developers choose HTSlib because it's the standardized, high-performance foundation for genomic data processing with minimal dependencies, proven reliability through its use in samtools and bcftools, and comprehensive support for modern sequencing formats.
Overview
C library for high-throughput sequencing data formats
Use Cases
Best For
- Building bioinformatics tools that need to read or write SAM/CRAM/VCF files
- Developing custom genomic data processing pipelines in C or C++
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