scMulan
A multitask generative pre-trained language model for zero-shot cell type annotation, batch integration, and conditional cell generation in single-cell transcriptomics.
Overview
Repository for paper scMulan: a multitask generative pre-trained language model for single-cell analysis.
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scGPTscGPT is a foundation model designed for single-cell multi-omics data analysis using generative AI. It leverages transformer architecture pretrained on millions of single-cell profiles to enable a wide range of downstream biological tasks, advancing computational biology by providing a powerful, unified model for cellular data. ## Key Features - **Pretrained Model Zoo** — Offers multiple organ-specific and whole-human models trained on millions of cells for various applications. - **Zero-Shot Applications** — Supports tasks like cell embedding and reference mapping without task-specific training. - **Reference Mapping** — Enables fast similarity search across millions of cells using efficient indexing with faiss. - **Multi-Task Fine-Tuning** — Can be adapted for scRNA-seq integration, cell type annotation, perturbation prediction, and GRN inference. - **Online Tools** — Provides accessible web applications for reference mapping, cell annotation, and GRN inference via cloud GPUs. ## Philosophy scGPT aims to build a foundational AI model for single-cell biology, democratizing access to advanced computational methods and accelerating discoveries in multi-omics research through open-source collaboration.
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