Protein Design

Evolutionary Scale Modeling (ESM)Python

A collection of transformer protein language models for predicting structure, function, and designing proteins from sequences.

RFdiffusionPython

An open-source diffusion model for generating and designing protein structures, including binders, symmetric oligomers, and motif-scaffolded proteins.

ESM3Python

A multimodal protein language model for generative protein design and engineering by jointly reasoning over sequence, structure, and function.

ProteinMPNNJupyter Notebook

A deep learning model for protein sequence design that generates amino acid sequences for given protein backbones.