ProteinGym
A comprehensive benchmark suite for evaluating protein fitness prediction models using deep mutational scanning and clinical variant data.
What is ProteinGym?
ProteinGym is a large-scale benchmark suite for evaluating protein fitness prediction models. It provides curated datasets from deep mutational scanning experiments and annotated human clinical variants to enable standardized comparisons of computational methods that predict how mutations affect protein function. The project addresses the need for rigorous, reproducible evaluation in protein engineering and variant interpretation.
Computational biologists, bioinformaticians, and machine learning researchers developing or applying models for protein fitness prediction, variant effect analysis, and protein design.
Developers choose ProteinGym because it offers a comprehensive, community-maintained benchmark with diverse datasets, standardized metrics, and an extensive leaderboard of state-of-the-art baselines, enabling fair model comparisons and accelerating research in protein fitness prediction.
Overview
Official repository for the ProteinGym benchmarks
Use Cases
Best For
- Benchmarking new protein fitness prediction models against established baselines
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