Ren'py

Godot

Godot Engine – Multi-platform 2D and 3D game engine

Three.js

JavaScript 3D Library.

pixi.js

The HTML5 Creation Engine: Create beautiful digital content with the fastest, most flexible 2D WebGL renderer.

Phaser

Phaser is a fun, free and fast 2D game framework for making HTML5 games for desktop and mobile web browsers, supporting Canvas and WebGL rendering.